Articles : Effects of Alendronate Administration and Treadmill Running on Bone Mineral Density in Glucocorticoid-induced Osteoporosis Rats

Journal of Exercise Nutrition & Biochemistry 2002;6(2):109-114.

Abstract

I
n the present study, 5 ㎎/㎏ BW glucocorticoid (GC) was used for loping osteoporosis. After this treatment, 5 ㎎/㎏ BW alendronate (A) was injected in the abdomen for the medical cure and exercise regimen was performed for weeks. Exercise-training was designed endurance exercise with treadmill exercise (TM), 28 m/min, 30 min/day, 5 day/week. Bone mineral density(BMD), bone mineral content(BMC), and bone intensity were measured with DEXA and Instron. Bone length and diameter were measured with caliper and blood calcium was analyzed with enzymatic method. Osteoporosis induced with GC was higher in BMC. In addition, BMD, intensity, bone length, diameter, and blood calcium was tended to reduce but not significantly different between treatments. GC-A group has increased BMD and blood calcium than other treatments (p<0.05). Diameter and intensity, however, were not significantly different. TM has increased bone length of GC-TM and GC-ATM compared to GC-A (p<0.05), however; diameter was not. These results suggested that only the exercise-training regimen after glucocorticoid-induced osteoporosis is too stressful in rats. Therefore, exercise training combined with alendronate administration is better method to increase those effects.