Orignal Paper : Effects of cardio/respiratory fitness and adiponectin single nucleotide polymorphism on clustering of metabolic risk factors in young Korean adults

doi:2011.15.2.79

Phys Act Nutr > Volume 15(2); 2011 > Article

Journal of Exercise Nutrition & Biochemistry 2011;15(2):79-86.
DOI: https://doi.org/10.5717/jenb.2011.15.2.79

Abstract

Little is known about whether or not cardio/respiratory fitness (CRF) modulates the genetic effect of adiponectin polymorphism on its outcome phenotypes. The aims of the study were to investigate whether or not the association between adiponectin gene SNP (+ 45T >G, rs2241766) and clustering of metabolic risk factors is modified by CRF in a study sample of 1025 young Korean adults (542 men and 483 women, mean age ranging between 19 and 26 years old). The clustering of metabolic risk factors was defined as the sum of Z scores for waist circumference (WC), blood pressure (BP), triglycerides (TG), high-density lipoprotein cholesterol, and fasting glucose. With respect to the SNP +45T/G, variant, a general linear model followed by post-hoc analysis showed that the TT genotype had a significantly higher BMI value compared to the GG genotype (P=0.035). Analyses based on CRF levels in a co-dominant model showed that the TT genotype had a significantly higher value for clustered risk score than the TG+GG genotype (P=0.005), but only in the low CRF subgroup. In summary, the present findings suggest that the SNP at position +45 is associated with clustering of metabolic risk factors, and the effects of the expression of the SNP are modulated by CRF.

Key Words: Metabolic syndrome, physical activity, fitness, genetic susceptibility, cross-sectional study