1.
Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes care. 2005;28:1769-78.
Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.
Diabetes care 2005;28:1769-78. PMID:
10.2337/diacare.28.7.1769. PMID:
15983333.
2.
Volk KM, Pogrebna VV, Roberts JA, Zachry JE, Blythe SN, Toporikova N. High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats. J Endocr Soc. 2017;1:1488-505.
Volk KM, Pogrebna VV, Roberts JA, Zachry JE, Blythe SN, Toporikova N. High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats.
J Endocr Soc 2017;1:1488-505. PMID:
10.1210/js.2017-00305. PMID:
29308444.
3.
Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol. 2013;62:569-76.
Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome.
J Am Coll Cardiol 2013;62:569-76. PMID:
23770180.
4.
Petry NM, Barry D, Pietrzak RH, Wagner JA. Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychosom Med. 2008;70:288-97.
Petry NM, Barry D, Pietrzak RH, Wagner JA. Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Psychosom Med 2008;70:288-97. PMID:
10.1097/psy.0b013e3181651651. PMID:
18378873.
5.
Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci. 2014;69:1339-52.
Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
J Gerontol A Biol Sci Med Sci 2014;69:1339-52. PMID:
10.1093/gerona/glu080. PMID:
24895269.
6.
Gerozissis K. Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies. Eur J Pharmacol. 2008;585:38-49.
Gerozissis K. Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies.
Eur J Pharmacol 2008;585:38-49. PMID:
10.1016/j.ejphar.2008.01.050. PMID:
18407262.
7.
Burns JM, Donnelly JE, Anderson HS, Mayo MS, Spencer- Gardner L, Thomas G, Cronk BB, Haddad Z, Klima D, Hansen D, Brooks WM. Peripheral insulin and brain structure in early Alzheimer disease. Neurology. 2007;69:1094-104.
Burns JM, Donnelly JE, Anderson HS, Mayo MS, Spencer-Gardner L, Thomas G, Cronk BB, Haddad Z, Klima D, Hansen D, Brooks WM. Peripheral insulin and brain structure in early Alzheimer disease.
Neurology 2007;69:1094-104. PMID:
10.1212/01.wnl.0000276952.91704.af. PMID:
17846409.
8.
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis. 2005;7:63-80.
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
J Alzheimers Dis 2005;7:63-80. PMID:
10.3233/jad-2005-7107. PMID:
15750215.
9.
Bassil F, Fernagut PO, Bezard E, Meissner WG. Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification? Prog Neurobiol. 2014;118:1-18.
Bassil F, Fernagut PO, Bezard E, Meissner WG. Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
Prog Neurobiol 2014;118:1-18. PMID:
10.1016/j.pneurobio.2014.02.005. PMID:
24582776.
10.
Ross AP, Bartness TJ, Mielke JG, Parent MB. A high fructose diet impairs spatial memory in male rats. Neurobiol Learn Mem. 2009;92:410-6.
Ross AP, Bartness TJ, Mielke JG, Parent MB. A high fructose diet impairs spatial memory in male rats.
Neurobiol Learn Mem 2009;92:410-6. PMID:
10.1016/j.nlm.2009.05.007. PMID:
19500683.
11.
Spielman LJ, Little JP, Klegeris A. Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration. J Neuroimmunol. 2014;273:8-21.
Spielman LJ, Little JP, Klegeris A. Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration.
J Neuroimmunol 2014;273:8-21. PMID:
10.1016/j.jneuroim.2014.06.004. PMID:
24969117.
12.
Kim YS, Morgan MJ, Choksi S, Liu ZG. TNF-induced activation
. Kim YS, Morgan MJ, Choksi S, Liu ZG. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.
Molecular cell 2007;26:675-87. PMID:
10.1016/j.molcel.2007.04.021. PMID:
17560373.
13.
Kang EB, Koo JH, Jang YC, Yang CH, Lee Y, Cosio-Lima LM, Cho JY. Neuroprotective Effects of Endurance Exercise Against High-Fat Diet-Induced Hippocampal Neuroinflammation. J Neuroendocrinol. 2016;28.
Kang EB, Koo JH, Jang YC, Yang CH, Lee Y, Cosio-Lima LM, Cho JY. Neuroprotective Effects of Endurance Exercise Against High-Fat Diet-Induced Hippocampal Neuroinflammation.
J Neuroendocrinol 2016;28:PMID:
10.1111/jne.12385.
14.
Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J Neurosci. 2000;20:2567-74.
Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal.
J Neurosci 2000;20:2567-74. PMID:
10729337.
15.
Maccioni RB, Munoz JP, Barbeito L. The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Arch Med Res. 2001;32:367-81.
Maccioni RB, Munoz JP, Barbeito L. The molecular bases of Alzheimer's disease and other neurodegenerative disorders.
Arch Med Res 2001;32:367-81. PMID:
10.1016/s0188-4409(01)00316-2. PMID:
11578751.
16.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D. Detrimental effects of diet-induced obesity on tau pathology are independent of insulin resistance in tau transgenic mice. Diabetes. 2013;62:1681-8.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier , Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D. Detrimental effects of diet-induced obesity on tau pathology are independent of insulin resistance in tau transgenic mice.
Diabetes 2013;62:1681-8. PMID:
23250356.
17.
Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada-Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. J Biol Chem. 2012;287:23024-33.
Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada-Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.
J Biol Chem 2012;287:23024-33. PMID:
22563077.
18.
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. J Nutr Biochem. 2014;25:634-41.
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status.
J Nutr Biochem 2014;25:634-41. PMID:
10.1016/j.jnutbio.2014.02.003. PMID:
24746833.
19.
Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2008;295:E586-94.
Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice.
Am J Physiol Endocrinol Metab 2008;295:E586-94. PMID:
10.1152/ajpendo.00309.2007. PMID:
18577694.
20.
Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415-45.
Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity.
Annu Rev Immunol 2011;29:415-45. PMID:
10.1146/annurev-immunol-031210-101322. PMID:
21219177.
21.
Zhang Y, Huang NQ, Yan F, Jin H, Zhou SY, Shi JS, Jin F. Diabetes mellitus and Alzheimer's disease: GSK-3beta as a potential link. Behav Brain Res. 2018;339:57-65.
Zhang Y, Huang NQ, Yan F, Jin H, Zhou SY, Shi JS, Jin F. Diabetes mellitus and Alzheimer's disease: GSK-3beta as a potential link.
Behav Brain Res 2018;339:57-65. PMID:
29158110.
22.
Takashima A. GSK-3 is essential in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2006;9:309-17.
Takashima A. GSK-3 is essential in the pathogenesis of Alzheimer's disease.
J Alzheimers Dis 2006;9:309-17. PMID:
10.3233/jad-2006-9s335. PMID:
16914869.
23.
Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallàs M. Longterm treadmill exercise induces neuroprotective molecular changes in rat brain. J Appl Physiol. 2011;111:1380-90.
Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallàs M. Longterm treadmill exercise induces neuroprotective molecular changes in rat brain.
J Appl Physiol 2011;111:1380-90. PMID:
10.1152/japplphysiol.00425.2011. PMID:
21817108.
24.
Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54.
Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Mol Neurodegener 2014;9:54PMID:
10.1186/1750-1326-9-54. PMID:
25432085.
25.
de la Monte SM, Longato L, Tong M, Wands JR. Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. Curr Opin Investig Drugs. 2009;10:1049-60.
de la Monte SM, Longato L, Tong M, Wands JR. Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.
Curr Opin Investig Drugs 2009;10:1049-60.
26.
Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol. 2001;177:125-34.
Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory.
Mol Cell Endocrinol 2001;177:125-34. PMID:
10.1016/s0303-7207(01)00455-5. PMID:
11377828.