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Journal of Exercise Nutrition & Biochemistry 2004;8(2):229-234.
Articles : Changes in Immune Status of Rats by Dietary Iron and Regular Exercise
This study was performed to investigate the changes in immune status of rats by dietary iron and regular exercise. Male Sprague Dawley rats (n = 40) were divided into 4 groups by dietary iron (Fe^(-), 5 ppm Fe vs. Fe^(+), 50 ppm Fe) and exercise (control vs. exercise). Rats were given experimental diets for 8 weeks. Regular treadmill exercise (6˚, 28 m/ min, 30 minutes duration) was given to exercise groups 5 days per week for 8 weeks. Iron deficient rats decreased hematocrit (47.5% vs. 39.8%) and hemoglobin concentration (16.0 g/dl vs. 12.3 g/dl) compared to iron sufficient rats and were in a marginal marginally iron-deficient-anemic status. Immunoglobulin(Ig) A level was significantly increased by regular exercise. IgG level was also significantly increased by regular exercise in Fe^(+) group, but was decreased in Fe^(-) group. Spleen cell proliferation by Con A stimulation showed an increasing tendency in exercising Fe^(+) group, but significant difference was not found. IL-2 concentration showed an increasing tendency with regular exercise, but statistical difference was not found. IL-2 and IFNy were not significantly affected by dietary iron level of this study. It is likely that regular exercise significantly increases plasma Ig A and sufficient supply of dietary iron is necessary for the enhancement of immune response with regular exercise.
Key Words: immunity, spleen, cytokine, immunoglobulin, iron, exercise, rat


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