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Journal of Exercise Nutrition & Biochemistry 2004;8(2):111-118.
Invited Review : A Role of Nuclear Factors for Mitochondrial Biogenesis by Exercise in Skeletal Muscle
Abstract
Enhancement of oxidative capacity in skeletal muscle is one of a major adaptation to endurance exercise training. This adaptation in skeletal muscle is completely dependent on the mitochondrial biogenesis. If the adaptation is integral (or additive) effects of each exercise bout, "exercise signal" should be transferred to nuclei as a signal of "mitochondrial biogenesis". Recent advance of the study demonstrated that some nuclear factors constitute the signaling pathway for mitochondrial biogenesis. These factors involve nuclear respiratory factor-1 (NRF-1), nuclear respiratory factor-2 (NRF-2), mitochondria] transcriptional factor A (mtTFA or Tfam), and peroxisome proliferators-activated receptor (PPAR) γ coactivator-la (PGC-lα). Especially, PGC-1α is believed to be a master regulator of mitochondrial biogenesis. This review will focus on the regulation of these nuclear factors by exercise for mitochondrial biogenesis in skeletal muscle.
Key Words: mitochondrial biogenesis, exercise, oxidative capacity, PPARγ


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