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Journal of Exercise Nutrition & Biochemistry 2004;8(1):73-78.
Articles : Effects of Carnitine and Hydroxycitrate Co-ingestion on Lipids Metabolism during Exercise in Rats
Abstract
C
arnitine is essential substance to fatty acid oxidation in mitochondria, where the β-oxidation take place. Hydroxycitrate is the principal acid of fruit of Garcinia cambogia, Garcinia indica, and Garcinia atroviridis. Hydroxycitrate is shown to be a potent inhibitor of ATP lyase, which catalyzes the extra mitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA: citrate + ATP + CoA → actyl-CoA + ADP + Pi + oxaloacetate. The purpose of this study is to examine the effects of carnitine and hydroxycitrate ingestion on lipid metabolism during exercise in rats. 28 male Sprague-Dawley rats were randomly assigned 4 groups (CON: control, HCA: HCA supplementation, CAR: carnitine supplementation, MIX: HCA+carnitine supplementation). All rats that have exercise trained and the diet supplemented in each group for 4weeks. Fat weight, blood glucose, lactate, FFA, TC, TG, HDL-C, LDL-C, Liver and muscle glycogen were analyzed. Total fat weight, TC and LDL-C were significantly decreased in the all experimental group (p<.05). Blood glucose concentration were significantly increased in the HCA and CAR (p<.05). FFA concentration were significantly decreased in the CAR and MIX (p<.05). Glycogen contents were significantly increased MIX (p<.05). These results suggested that 4weeks administration of camitine and hydroxycitrate promotes lipid oxidation and spares carbohydrate utilization during exercise in rat.
Key Words: Carnitine, HCA, Exercise, Lipid metabolism, Rats


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