1. Heinonen S, Buzkova J, Muniandy M, Kaksonen R, Ollikainen M, Ismail K, Hakkarainen A, Lundbom J, Lundbom N, Vuolteenaho K, Moilanen E, Kaprio J, Rissanen A, Suomalainen A, Pietilainen KH.. Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.
Diabetes 2015;64:3135-45. PMID:
25972572.
2. Johnson AR, Milner JJ, Makowski L.. The inflammation highway: metabolism accelerates inflammatory traffic in obesity.
Immunol Rev 2012;249:218-38. PMID:
10.1111/j.1600-065x.2012.01151.x. PMID:
22889225.
3. Maury E, Brichard SM.. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome.
Mol Cell Endocrinol 2010;314:1-16. PMID:
10.1016/j.mce.2009.07.031. PMID:
19682539.
4. Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ.. Extension of life-span with superoxide dismutase/catalase mimetics.
Science 2000;289:1567-9. PMID:
10.1126/science.289.5484.1567. PMID:
10968795.
5. Park KW, Baik HH, Jin BK.. IL-13-induced oxidative stress via microglial NADPH oxidase contributes to death of hippocampal neurons in vivo.
J Immunol 2009;183:4666-74. PMID:
10.4049/jimmunol.0803392. PMID:
19752235.
6. Hernandes MS, D'Avila JC, Trevelin SC, Reis PA, Kinjo ER, Lopes LR, Castro-Faria-Neto HC, Cunha FQ, Britto LR, Bozza FA.. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis.
J Neuroinflammation 2014;11:36PMID:
10.1186/1742-2094-11-36. PMID:
24571599.
7. Serrano F, Kolluri NS, Wientjes FB, Card JP, Klann E.. NADPH oxidase immunoreactivity in the mouse brain.
Brain Res 2003;988:193-8. PMID:
10.1016/s0006-8993(03)03364-x. PMID:
14519542.
8. Archer SL.. Mitochondrial dynamics--mitochondrial fission and fusion in human diseases.
N Engl J Med 2013;369:2236-51. PMID:
10.1056/nejmra1215233. PMID:
24304053.
9. Hall AR, Burke N, Dongworth RK, Hausenloy DJ.. Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease.
Br J Pharmacol 2014;171:1890-906. PMID:
10.1111/bph.12516. PMID:
24328763.
10. Zhan M, Brooks C, Liu F, Sun L, Dong Z.. Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology.
Kidney Int 2013;83:568-81. PMID:
10.1038/ki.2012.441. PMID:
23325082.
11. Chen H, Chan DC.. Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.
Hum Mol Genet 2009;18:R169-76. PMID:
10.1093/hmg/ddp326. PMID:
19808793.
12. Held NM, Houtkooper RH.. Mitochondrial quality control pathways as determinants of metabolic health.
Bioessays 2015;37:867-76. PMID:
10.1002/bies.201500013. PMID:
26010263.
13. Roy M, Reddy PH, Iijima M, Sesaki H.. Mitochondrial division and fusion in metabolism.
Curr Opin Cell Biol 2015;33:111-8. PMID:
10.1016/j.ceb.2015.02.001. PMID:
25703628.
14. Naudi A, Jove M, Ayala V, Cassanye A, Serrano J, Gonzalo H, Boada J, Prat J, Portero-Otin M, Pamplona R.. Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.
Exp Diabetes Res 2012;2012:696215PMID:
10.1155/2012/696215. PMID:
22253615.
15. Reeve AK, Krishnan KJ, Turnbull DM.. Age related mitochondrial degenerative disorders in humans.
Biotechnol J 2008;3:750-6. PMID:
10.1002/biot.200800066. PMID:
18512864.
16. Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP, Sotgia F.. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.
Cell Cycle 2013;12:172-82. PMID:
23257779.
17. Dahlmans D, Houzelle A, Schrauwen P, Hoeks J.. Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease.
Clin Sci (Lond) 2016;130:843-52. PMID:
10.1042/cs20150780. PMID:
27129097.
18. Tak H, Kim J, Jayabalan AK, Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK.. miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor.
Exp Mol Med 2014 46:e123. PMID:
10.1038/emm.2014.73.
19. Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, Takeichi Y, Sakamoto S, Yokota S, Mihara K, Kang D, Ishihara N, Takayanagi R, Nomura M.. Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.
Diabetologia 2015;58:2371-80. PMID:
10.1007/s00125-015-3704-7. PMID:
26233250.
20. Manczak M, Calkins MJ, Reddy PH.. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Hum Mol Genet 2011;20:2495-509. PMID:
10.1093/hmg/ddr139. PMID:
21459773.
21. Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X.. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
J Neurosci 2009;29:9090-103. PMID:
10.1523/jneurosci.1357-09.2009. PMID:
19605646.
22. Fealy CE, Mulya A, Lai N, Kirwan JP.. Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle.
J Appl Physiol 2014;117:239-45. PMID:
10.1152/japplphysiol.01064.2013. PMID:
24947026.
23. Bernardo TC, Marques-Aleixo I, Beleza J, Oliveira PJ, Ascensao A, Magalhaes J.. Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.
Brain Pathol 2016;26:648-63. PMID:
10.1111/bpa.12403. PMID:
27328058.
24. Chuang CS, Chang JC, Cheng FC, Liu KH, Su HL, Liu CS.. Modulation of mitochondrial dynamics by treadmill training to improve gait and mitochondrial deficiency in a rat model of Parkinson's disease.
Life Sci 2017;191:236-44. PMID:
10.1016/j.lfs.2017.10.003. PMID:
28986095.
25. Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT.. Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice.
Exp Gerontol 2017;90:1-13. PMID:
10.1016/j.exger.2017.01.013. PMID:
28108329.
26. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL.. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.
Mol Metab 2019;21:51-67. PMID:
30591411.
27. Kang EB, Koo JH, Jang YC, Yang CH, Lee Y, Cosio-Lima LM, Cho JY.. Neuroprotective Effects of Endurance Exercise Against High-Fat Diet-Induced Hippocampal Neuroinflammation.
J Neuroendocrinol 2016;28:PMID:
10.1111/jne.12385.
28. O'Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP.. Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat.
J Appl Physiol 2006;100:1584-9. PMID:
16373444.
29. Rice B, Janssen I, Hudson R, Ross R.. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men.
Diabetes Care 1999;22:684-91. PMID:
10.2337/diacare.22.5.684. PMID:
10332666.
30. Irving BA, Davis CK, Brock DW, Weltman JY, Swift D, Barrett EJ, Gaesser GA, Weltman A.. Effect of exercise training intensity on abdominal visceral fat and body composition.
Med Sci Sports Exerc 2008;40:1863-72. PMID:
10.1249/mss.0b013e3181801d40. PMID:
18845966.
31. Rege SD, Kumar S, Wilson DN, Tamura L, Geetha T, Mathews ST, Huggins KW, Broderick TL, Babu JR.. Resveratrol protects the brain of obese mice from oxidative damage.
Oxid Med Cell Longev 2013;2013:419092PMID:
10.1155/2013/419092. PMID:
24163719.
32. Sahin K, Orhan C, Tuzcu M, Sahin N, Ozdemir O, Juturu V.. Ingested capsaicinoids can prevent low-fat-high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways.
J Inflamm Res 2017;10:161-8. PMID:
29180887.
33. Lee S, Park Y, Dellsperger KC, Zhang C.. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice.
Am J Physiol Heart Circ Physiol 2011;301:H306-14. PMID:
10.1152/ajpheart.01306.2010. PMID:
21602470.
34. Ji LL.. Exercise and oxidative stress: role of the cellular antioxidant systems.
Exerc Sport Sci Rev 1995;23:135-66. PMID:
7556349.
35. Sen CK.. Oxidants and antioxidants in exercise.
J Appl Physiol 1995;79:675-86. PMID:
8567503.
36. Bertholet AM, Delerue T, Millet AM, Moulis MF, David C, Daloyau M, Arnaune-Pelloquin L, Davezac N, Mils V, Miquel MC, Rojo M, Belenguer P.. Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity.
Neurobiol Dis 2016;90:3-19. PMID:
26494254.
37. Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, Daugaard JR, Lloberas J, Camps M, Zierath JR, Rabasa-Lhoret R, Wallberg-Henriksson H, Laville M, Palacin M, Vidal H, Rivera F, Brand M, Zorzano A.. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism.
A novel regulatory mechanism altered in obesity. J Biol Chem 2003;278:17190-7. PMID:
10.1074/jbc.m212754200. PMID:
12598526.
38. Liu R, Jin P, Yu L, Wang Y, Han L, Shi T, Li X.. Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle.
PLoS One 2014 9:e92810. PMID:
10.1371/journal.pone.0092810.
39. Axelrod CL, Fealy CE, Mulya A, Kirwan JP.. Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype.
Acta Physiol (Oxf) 2019 255:e13216.
40. Konopka AR, Suer MK, Wolff CA, Harber MP.. Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training.
J Gerontol A Biol Sci Med Sci 2014;69:371-8. PMID:
10.1093/gerona/glt107. PMID:
23873965.
41. Zampieri S, Mammucari C, Romanello V, Barberi L, Pietrangelo L, Fusella A, Mosole S, Gherardi G, Hofer C, Lofler S, Sarabon N, Cvecka J, Krenn M, Carraro U, Kern H, Protasi F, Musaro A, Sandri M, Rizzuto R.. Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics.
Physiol Rep 2016 4:e13005. PMID:
10.14814/phy2.13005.